[HTML][HTML] Selective involvement of ceramide in cytokine-induced apoptosis: ceramide inhibits phorbol ester activation of nuclear factor κB
Among its diverse biologic effects, the cytokine tumor necrosis factor α causes the rapid
nuclear translocation of the transcription factor, nuclear factor κB (NF-κB). The p55 tumor
necrosis factor (TNF) receptor shares with the related APO-1/Fas antigen the ability to initiate
apoptosis. We investigated the role of the sphingolipid mediator ceramide in the cytokine-
induced signaling mechanisms leading to NF-κB activation and cell death. Several lines of
evidence presented here suggest that ceramide generated in response to TNFα or Fas …
nuclear translocation of the transcription factor, nuclear factor κB (NF-κB). The p55 tumor
necrosis factor (TNF) receptor shares with the related APO-1/Fas antigen the ability to initiate
apoptosis. We investigated the role of the sphingolipid mediator ceramide in the cytokine-
induced signaling mechanisms leading to NF-κB activation and cell death. Several lines of
evidence presented here suggest that ceramide generated in response to TNFα or Fas …