[HTML][HTML] Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine
C Bedia, J Casas, N Andrieu-Abadie, G Fabrias… - Journal of Biological …, 2011 - ASBMB
Dacarbazine (DTIC) is the treatment of choice for metastatic melanoma, but its response in
patients remains very poor. Ceramide has been shown to be a death effector and to play an
important role in regulating cancer cell growth upon chemotherapy. Among ceramidases,
the enzymes that catabolize ceramide, acid ceramidase (aCDase) has been implicated in
cancer progression. Here we show that DTIC elicits a time-and dose-dependent decrease of
aCDase activity and an increase of intracellular ceramide levels in human A375 melanoma …
patients remains very poor. Ceramide has been shown to be a death effector and to play an
important role in regulating cancer cell growth upon chemotherapy. Among ceramidases,
the enzymes that catabolize ceramide, acid ceramidase (aCDase) has been implicated in
cancer progression. Here we show that DTIC elicits a time-and dose-dependent decrease of
aCDase activity and an increase of intracellular ceramide levels in human A375 melanoma …