[HTML][HTML] Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-α-induced PGE2 production
YH Zeidan, BJ Pettus, S Elojeimy, T Taha… - Journal of biological …, 2006 - ASBMB
Sphingolipids are well established effectors of signal transduction downstream of the tumor
necrosis factor (TNF) receptor. In a previous study, we showed that the sphingosine
kinase/sphingosine 1-phosphate (S1P) pathway couples TNF receptor to induction of the
cyclooxygenase 2 gene and prostaglandin synthesis (Pettus, BJ, Bielawski, J., Porcelli, AM,
Reames, DL, Johnson, KR, Morrow, J., Chalfant, CE, Obeid, LM, and Hannun, YA (2003)
FASEB J. 17, 1411-1421). In this study, the requirement for acid sphingomyelinase and …
necrosis factor (TNF) receptor. In a previous study, we showed that the sphingosine
kinase/sphingosine 1-phosphate (S1P) pathway couples TNF receptor to induction of the
cyclooxygenase 2 gene and prostaglandin synthesis (Pettus, BJ, Bielawski, J., Porcelli, AM,
Reames, DL, Johnson, KR, Morrow, J., Chalfant, CE, Obeid, LM, and Hannun, YA (2003)
FASEB J. 17, 1411-1421). In this study, the requirement for acid sphingomyelinase and …