Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients
V Rebmann, P Schütt, D Brandhorst, B Opalka… - Clinical …, 2007 - Elsevier
Major histocompatibility complex class I-related chain A (MICA) molecules are frequently
expressed in lymphoproliferative malignancies including multiple myeloma (MM). MICA
activates NK cells and co-stimulates T cells by interaction with its immunoreceptor NKG2D.
In contrast, soluble MICA (sMICA) molecules impair the functions of NKG2D+ T and NK cells,
which may facilitate tumor cell escape from immunosurveillance. Here, we analyzed the
clinical relevance of sMICA in 97 MM patients. sMICA (mean±SEM pg/ml) was significantly …
expressed in lymphoproliferative malignancies including multiple myeloma (MM). MICA
activates NK cells and co-stimulates T cells by interaction with its immunoreceptor NKG2D.
In contrast, soluble MICA (sMICA) molecules impair the functions of NKG2D+ T and NK cells,
which may facilitate tumor cell escape from immunosurveillance. Here, we analyzed the
clinical relevance of sMICA in 97 MM patients. sMICA (mean±SEM pg/ml) was significantly …