Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients
HR Salih, D Goehlsdorf, A Steinle - Human immunology, 2006 - Elsevier
MICA, a ligand of the activating immunoreceptor NKG2D, is released by tumor cells in a
soluble form and can be detected in sera of tumor patients at significant levels. Soluble
MICA has been proposed to counteract NKG2D-mediated immunosurveillance of tumors.
Here, we report that MICB, the second member of the human MIC protein family, is likewise
shed by metalloproteases from tumor cells and is present in sera of patients with
gastrointestinal tumors. While cell-bound MICB causes downregulation of surface NKG2D …
soluble form and can be detected in sera of tumor patients at significant levels. Soluble
MICA has been proposed to counteract NKG2D-mediated immunosurveillance of tumors.
Here, we report that MICB, the second member of the human MIC protein family, is likewise
shed by metalloproteases from tumor cells and is present in sera of patients with
gastrointestinal tumors. While cell-bound MICB causes downregulation of surface NKG2D …