[HTML][HTML] Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism
Protein kinase A (PKA) has long been recognized as playing a major role in many regulatory
processes in cells through its activation by the ubiquitous second messenger cAMP. We
show here a novel mode of activation of PKA type II that is independent of cAMP and is,
instead, dependent on sphingosine. PKA type II is specifically activated by sphingosine and
its analog, dimethylsphingosine, but not by sphingosine-1-phosphate or other lipids. Like
cAMP, sphingosine activates PKA holoenzyme but not the catalytic subunit alone …
processes in cells through its activation by the ubiquitous second messenger cAMP. We
show here a novel mode of activation of PKA type II that is independent of cAMP and is,
instead, dependent on sphingosine. PKA type II is specifically activated by sphingosine and
its analog, dimethylsphingosine, but not by sphingosine-1-phosphate or other lipids. Like
cAMP, sphingosine activates PKA holoenzyme but not the catalytic subunit alone …