In mammalian cells, iron is required for the function of many prosthetic groups, including
heme and iron-sulfur clusters. Mammals absorb dietary iron and heme across the apical
mucosa of duodenal epithelial cells using a Fe2 transporter known as divalent metal
transporter 1 (DMT-1; also known as solute carrier family 11 member 2, divalent cation
transporter 1 (DCT1), and natural resistance associated macrophage protein 2)(1) or a
specific heme transporter, heme carrier protein 1 (2). On the basolateral membrane …