Urinary hepcidin-25 and risk of acute kidney injury following cardiopulmonary bypass
J Ho, M Reslerova, B Gali, A Gao… - Clinical Journal of the …, 2011 - journals.lww.com
Results Urinary hepcidin-25/Cr ratio was significantly elevated in all patients at POD 1
compared with baseline (P< 0.0005) and was also significantly elevated in non-AKI versus
AKI patients at POD 1 (P< 0.0005). Increased log 10 hepcidin-25/Cr ratio was strongly
associated with avoidance of AKI on univariate analysis. On multivariate analysis, the log 10
hepcidin-25/Cr ratio (P< 0.0001) was associated with avoidance of AKI with an area under
the curve of 0.80, sensitivity 0.68, specificity 0.68, and negative predictive value 0.96 …
compared with baseline (P< 0.0005) and was also significantly elevated in non-AKI versus
AKI patients at POD 1 (P< 0.0005). Increased log 10 hepcidin-25/Cr ratio was strongly
associated with avoidance of AKI on univariate analysis. On multivariate analysis, the log 10
hepcidin-25/Cr ratio (P< 0.0001) was associated with avoidance of AKI with an area under
the curve of 0.80, sensitivity 0.68, specificity 0.68, and negative predictive value 0.96 …