[HTML][HTML] PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence
MF Gaumont-Leclerc, UK Mukhopadhyay… - Journal of Biological …, 2004 - ASBMB
Oncogenic ras activates multiple signaling pathways to enforce cell proliferation in tumor
cells. The ERK1/2 mitogen-activated protein kinase pathway is required for the transforming
effects of ras, and its activation is often sufficient to convey mitogenic stimulation. However,
in some settings oncogenic ras triggers a permanent cell cycle arrest with features of cellular
senescence. How the Ras/ERK1/2 pathway activates different cellular programs is not well
understood. Here we show that ERK1/2 localize predominantly in the cytoplasm during ras …
cells. The ERK1/2 mitogen-activated protein kinase pathway is required for the transforming
effects of ras, and its activation is often sufficient to convey mitogenic stimulation. However,
in some settings oncogenic ras triggers a permanent cell cycle arrest with features of cellular
senescence. How the Ras/ERK1/2 pathway activates different cellular programs is not well
understood. Here we show that ERK1/2 localize predominantly in the cytoplasm during ras …