Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study
Objective To determine whether extracellular concentrations of glutamate and other amino
acids are significantly elevated after intracerebral hemorrhage and, if so, the temporal
characteristics of these changes. Although the role of excitotoxic amino acids, particularly
that of glutamate, has been described in ischemic stroke and head trauma, no information
exists regarding their possible contribution to the pathogenesis of neuronal injury in
intracerebral hemorrhage. Design
acids are significantly elevated after intracerebral hemorrhage and, if so, the temporal
characteristics of these changes. Although the role of excitotoxic amino acids, particularly
that of glutamate, has been described in ischemic stroke and head trauma, no information
exists regarding their possible contribution to the pathogenesis of neuronal injury in
intracerebral hemorrhage. Design