[HTML][HTML] Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain
D Vondrackova, P Leyendecker, W Meissner, M Hopp… - The Journal of …, 2008 - Elsevier
This randomized, double-blinded, placebo-and active-controlled, parallel-group study was
designed to demonstrate the superiority of oxycodone in combination with naloxone in a
prolonged release (PR) formulation over placebo with respect to analgesic efficacy. The
active control group was included for sensitivity and safety analyses, and furthermore to
compare the analgesic efficacy and bowel function of oxycodone PR/naloxone PR with
oxycodone PR alone. The analgesic efficacy was measured as the time from the initial dose …
designed to demonstrate the superiority of oxycodone in combination with naloxone in a
prolonged release (PR) formulation over placebo with respect to analgesic efficacy. The
active control group was included for sensitivity and safety analyses, and furthermore to
compare the analgesic efficacy and bowel function of oxycodone PR/naloxone PR with
oxycodone PR alone. The analgesic efficacy was measured as the time from the initial dose …