Inherited epidermolysis bullosa: new diagnostic criteria and classification
LRA Intong, DF Murrell - Clinics in dermatology, 2012 - Elsevier
Epidermolysis bullosa (EB) is a group of inherited, mechanobullous disorders caused by
mutations in various structural proteins in the skin. There have been several advances in the
classification of EB since it was first introduced in the late 19th century. We now recognize
four major types of EB, depending on the location of the target proteins and level of the
blisters: EB simplex (epidermolytic), junctional EB (lucidolytic), dystrophic EB (dermolytic),
and Kindler syndrome (mixed levels of blistering). This contribution will summarize the most …
mutations in various structural proteins in the skin. There have been several advances in the
classification of EB since it was first introduced in the late 19th century. We now recognize
four major types of EB, depending on the location of the target proteins and level of the
blisters: EB simplex (epidermolytic), junctional EB (lucidolytic), dystrophic EB (dermolytic),
and Kindler syndrome (mixed levels of blistering). This contribution will summarize the most …