[HTML][HTML] Pregnancy-specific glycoprotein 1 induces endothelial tubulogenesis through interaction with cell surface proteoglycans
FA Lisboa, J Warren, G Sulkowski, M Aparicio… - Journal of Biological …, 2011 - ASBMB
Pregnancy-specific β1 glycoproteins (PSGs) are the most abundant fetal proteins in the
maternal bloodstream in late pregnancy. They are secreted by the syncytiotrophoblast and
are detected around day 14 postfertilization. There are 11 human PSG genes, which encode
a family of proteins exhibiting significant conservation at the amino acid level. We and others
have proposed that PSGs have an immune modulatory function. In addition, we recently
postulated that they are proangiogenic due to their ability to induce the secretion of VEGF-A …
maternal bloodstream in late pregnancy. They are secreted by the syncytiotrophoblast and
are detected around day 14 postfertilization. There are 11 human PSG genes, which encode
a family of proteins exhibiting significant conservation at the amino acid level. We and others
have proposed that PSGs have an immune modulatory function. In addition, we recently
postulated that they are proangiogenic due to their ability to induce the secretion of VEGF-A …