Elevated expression of KiSS-1 in placenta of preeclampsia and its effect on trophoblast
H Zhang, Q Long, L Ling, A Gao, H Li, Q Lin - Reproductive biology, 2011 - Elsevier
The expression of KiSS-1, MMP-9 and MMP-2 mRNAs and proteins was studied in
placentas of women with preeclampsia (PE, n= 47) and women of normal pregnancy (NP;
n= 30). In addition, KiSS-1 mRNA expression as well as cell growth, proliferation and
invasion were examined in JAR cells (human trophoblast cell line) transfected with pcDNA3-
KiSS-1vector. Expression of KiSS-1 mRNA and protein was higher (p< 0.05) in women with
PE compared with that of NP women. In contrast, expression of MMP-9 and MMP-2 was …
placentas of women with preeclampsia (PE, n= 47) and women of normal pregnancy (NP;
n= 30). In addition, KiSS-1 mRNA expression as well as cell growth, proliferation and
invasion were examined in JAR cells (human trophoblast cell line) transfected with pcDNA3-
KiSS-1vector. Expression of KiSS-1 mRNA and protein was higher (p< 0.05) in women with
PE compared with that of NP women. In contrast, expression of MMP-9 and MMP-2 was …