Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation
N Sharma, C Timmers, P Trikha, HI Saavedra… - Journal of biological …, 2006 - ASBMB
The E2F family of transcription factors is believed to have an essential role in the control of
cellular proliferation by regulating the transcription of genes involved in cell cycle
progression. Previous work has demonstrated that the targeted inactivation of E2f1, E2f2,
and E2f3 results in elevated p21 CIP1 protein levels, loss of E2F target gene expression,
and cell cycle arrest at G 1/S and G 2/M, suggesting a strict requirement for these E2Fs in the
control of normal cellular proliferation. We now demonstrate that E2f1, E2f2, and E2f3 are …
cellular proliferation by regulating the transcription of genes involved in cell cycle
progression. Previous work has demonstrated that the targeted inactivation of E2f1, E2f2,
and E2f3 results in elevated p21 CIP1 protein levels, loss of E2F target gene expression,
and cell cycle arrest at G 1/S and G 2/M, suggesting a strict requirement for these E2Fs in the
control of normal cellular proliferation. We now demonstrate that E2f1, E2f2, and E2f3 are …
