[HTML][HTML] The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the …
Haematologica, 2010•ncbi.nlm.nih.gov
Background Recently, in genome-wide analyses of DNA copy number abnormalities using
single nucleotide polymorphism microarrays, genetic alterations targeting PAX5 were
identified in over 30% of pediatric patients with acute lymphoblastic leukemia. So far the
occurrence of PAX5 alterations and their clinical correlation have not been investigated in
adults with BCR-ABL1-positive acute lymphoblastic leukemia.
single nucleotide polymorphism microarrays, genetic alterations targeting PAX5 were
identified in over 30% of pediatric patients with acute lymphoblastic leukemia. So far the
occurrence of PAX5 alterations and their clinical correlation have not been investigated in
adults with BCR-ABL1-positive acute lymphoblastic leukemia.
Abstract
Background
Recently, in genome-wide analyses of DNA copy number abnormalities using single nucleotide polymorphism microarrays, genetic alterations targeting PAX5 were identified in over 30% of pediatric patients with acute lymphoblastic leukemia. So far the occurrence of PAX5 alterations and their clinical correlation have not been investigated in adults with BCR-ABL1-positive acute lymphoblastic leukemia.
ncbi.nlm.nih.gov
