Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia
T Inaba, WM Roberts, LH Shapiro, KW Jolly… - Science, 1992 - science.org
T Inaba, WM Roberts, LH Shapiro, KW Jolly, SC Raimondi, SD Smith, AT Look
Science, 1992•science.orgA t (17; 19) chromosomal translocation in early B-lineage acute leukemia was shown to
result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix
transcription factor gene on chromosome 19, fused to sequences from a previously
unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The
chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the
carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed …
result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix
transcription factor gene on chromosome 19, fused to sequences from a previously
unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The
chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the
carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed …
A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed in liver and kidney, but not in lymphoid cells, and was found to be closely related to the leucine zipper-containing transcription factors DBP (albumin D-box binding protein) and TEF (thyrotroph embryonic factor), which regulate developmental stage-specific gene expression.
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