Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia
AA Ferrando, AT Look - Seminars in hematology, 2000 - Elsevier
Comprehensive study of the major chromosomal/molecular abnormalities in children and
adults with acute lymphoblastic leukemia (ALL) has demonstrated prognostic utility for many
of these anomalies, to the extent that cytogenetic and molecular genetic evaluations are now
required for optimal clinical management of newly diagnosed cases. For example, the t (12;
21)/TEL-AML1 (ETV6-CBFA2) or hyperdiploid karyotypes each identifies subgroups of
children who can be cured with well-tolerated chemotherapy based primarily on drugs with …
adults with acute lymphoblastic leukemia (ALL) has demonstrated prognostic utility for many
of these anomalies, to the extent that cytogenetic and molecular genetic evaluations are now
required for optimal clinical management of newly diagnosed cases. For example, the t (12;
21)/TEL-AML1 (ETV6-CBFA2) or hyperdiploid karyotypes each identifies subgroups of
children who can be cured with well-tolerated chemotherapy based primarily on drugs with …