Bcl‐10 protein highly correlates with the expression of phosphorylated p65 NF‐κB in peripheral T‐cell lymphomas and is associated with clinical outcome
J Briones, E Moga, I Espinosa, C Vergara… - …, 2009 - Wiley Online Library
Histopathology, 2009•Wiley Online Library
Aims: In T cells, protein kinase C (PKC) θ plays a major role in T‐cell receptor (TCR)‐
mediated activation of a novel nuclear factor (NF)‐κB pathway that involves phosphorylation
of p65 at serine 536 (Pp65Ser536). Bcl‐10 acts along the same pathway downstream of
PKC θ to activate NF‐κB. The aim was to investigate the relationship between the
expression of PKC θ, Bcl‐10 and P‐p65Ser536 proteins and their prognostic significance in
peripheral T‐cell lymphomas (PTCLs). Methods and results: Paraffin‐embedded tissues …
mediated activation of a novel nuclear factor (NF)‐κB pathway that involves phosphorylation
of p65 at serine 536 (Pp65Ser536). Bcl‐10 acts along the same pathway downstream of
PKC θ to activate NF‐κB. The aim was to investigate the relationship between the
expression of PKC θ, Bcl‐10 and P‐p65Ser536 proteins and their prognostic significance in
peripheral T‐cell lymphomas (PTCLs). Methods and results: Paraffin‐embedded tissues …
Aims: In T cells, protein kinase C (PKC) θ plays a major role in T‐cell receptor (TCR)‐mediated activation of a novel nuclear factor (NF)‐κB pathway that involves phosphorylation of p65 at serine 536 (Pp65Ser536). Bcl‐10 acts along the same pathway downstream of PKC θ to activate NF‐κB. The aim was to investigate the relationship between the expression of PKC θ, Bcl‐10 and P‐p65Ser536 proteins and their prognostic significance in peripheral T‐cell lymphomas (PTCLs).
Methods and results: Paraffin‐embedded tissues from 30 patients with PTCLs treated with curative intention were evaluated retrospectively. Expression of PKC θ, Bcl‐10 and P‐p65Ser536 proteins was assessed using immunohistochemistry. Expression of PKC θ was detected in 22 of 30 cases (73%), Bcl‐10 in 20 of 30 (67%) and P‐p65Ser536 in 21 of 30 (70%). Bcl‐10+ tumours were associated with PKC θ (18 of 22) (P < 0.0001) and Pp65Ser536 (19 of 21) expression (P < 0.0001). Patients with Bcl‐10+ or P‐p65Ser536+ tumours fared better, with a 5‐year overall survival of 48 and 45%, respectively, versus 0% for negative tumours (P = 0.029 and P = 0.04, respectively).
Conclusions: Bcl‐10 is expressed in PTCLs, correlates with PKC θ and Pp65Ser536 expression and seems to be associated with better survival.
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