Insulin receptors in the mammalian central nervous system: binding characteristics and subunit structure
S Gammeltoft, M Fehlmann, E Van Obberghen - Biochimie, 1985 - Elsevier
Insulin receptors in rat and human central nervous system have been identified by binding of
125 I-insulin on purified synaptic plasma membranes; affinity labelling of receptors by
chemical cross-linking 125 I-insulin; or phosphorylation of receptors with [γ-32 P] ATP. Brain
insulin receptors showed significant differences in their binding characteristics and subunit
structure when compared with receptors in other tissues like adipose and liver cells:(1)
absence of negatively cooperative interactions;(2) a distinct binding specificity ie porcine …
125 I-insulin on purified synaptic plasma membranes; affinity labelling of receptors by
chemical cross-linking 125 I-insulin; or phosphorylation of receptors with [γ-32 P] ATP. Brain
insulin receptors showed significant differences in their binding characteristics and subunit
structure when compared with receptors in other tissues like adipose and liver cells:(1)
absence of negatively cooperative interactions;(2) a distinct binding specificity ie porcine …
