The abnormal metabolic state that accompanies diabetes renders arteries susceptible to
atherosclerosis, being capable of altering the functional properties of multiple cell types,
including endothelium and platelets. In particular, an altered platelet metabolism and
changes in intraplatelet signaling pathways may contribute to the pathogenesis of
atherothrombotic complications of diabetes. A variety of mechanisms may be responsible for
enhanced platelet aggregation. Among them, hyperglycemia may represent a causal factor …