Elevated serum cytokines during human anaphylaxis: identification of potential mediators of acute allergic reactions
SF Stone, C Cotterell, GK Isbister, A Holdgate… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Anaphylaxis is generally unanticipated and requires emergency
management. Therefore, the biological mediators in human beings have been difficult to
define. OBJECTIVE: Our aim was to identify cytokines and chemokines whose
concentrations increase during anaphylaxis in human beings and to determine how each
correlates with severity. METHODS: We measured the concentrations of potential mediators,
including cytokines, chemokines, mast cell tryptase (MCT), and histamine, over 3 time points …
management. Therefore, the biological mediators in human beings have been difficult to
define. OBJECTIVE: Our aim was to identify cytokines and chemokines whose
concentrations increase during anaphylaxis in human beings and to determine how each
correlates with severity. METHODS: We measured the concentrations of potential mediators,
including cytokines, chemokines, mast cell tryptase (MCT), and histamine, over 3 time points …
