Overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking ATP-sensitive K+ channels by improving the triggering Ca2+ signal
A Szollosi, M Nenquin, JC Henquin - Journal of biological chemistry, 2007 - ASBMB
A current model ascribes glucose-induced insulin secretion to the interaction of a triggering
pathway (K ATP channel-dependent Ca 2+ influx and rise in cytosolic [Ca 2+] c) and an
amplifying pathway (K ATP channel-independent augmentation of secretion without further
increase of [Ca 2+] c). However, several studies of sulfonylurea receptor 1 null mice
(Sur1KO) failed to measure significant effects of glucose in their islets lacking K ATP
channels. We addressed this issue that challenges the model. Compared with controls, fresh …
pathway (K ATP channel-dependent Ca 2+ influx and rise in cytosolic [Ca 2+] c) and an
amplifying pathway (K ATP channel-independent augmentation of secretion without further
increase of [Ca 2+] c). However, several studies of sulfonylurea receptor 1 null mice
(Sur1KO) failed to measure significant effects of glucose in their islets lacking K ATP
channels. We addressed this issue that challenges the model. Compared with controls, fresh …
