Preclinical behavioral models for predicting antipsychotic activity
V Castagné, PC Moser, RD Porsolt - Advances in pharmacology, 2009 - Elsevier
Schizophrenia is a major psychiatric disease that is characterized by three distinct symptom
domains: positive symptoms, negative symptoms, and cognitive impairment. Additionally,
treatment with classical antipsychotic medication can be accompanied by important side
effects that involve extrapyramidal symptoms (EPS). The discovery of clozapine in the
1970s, which is efficacious in all three symptom domains and has a reduced propensity to
induce EPS, has driven research for new antipsychotic agents with a wider spectrum of …
domains: positive symptoms, negative symptoms, and cognitive impairment. Additionally,
treatment with classical antipsychotic medication can be accompanied by important side
effects that involve extrapyramidal symptoms (EPS). The discovery of clozapine in the
1970s, which is efficacious in all three symptom domains and has a reduced propensity to
induce EPS, has driven research for new antipsychotic agents with a wider spectrum of …
