[HTML][HTML] Genetic causes of high and low serum HDL-cholesterol
D Weissglas-Volkov, P Pajukanta - Journal of lipid research, 2010 - ASBMB
Plasma levels of HDL cholesterol (HDL-C) have a strong inherited basis with heritability
estimates of 40-60%. The well-established inverse relationship between plasma HDL-C
levels and the risk of coronary artery disease (CAD) has led to an extensive search for
genetic factors influencing HDL-C concentrations. Over the past 30 years, candidate gene,
genome-wide linkage, and most recently genome-wide association (GWA) studies have
identified several genetic variations for plasma HDL-C levels. However, the functional role of …
estimates of 40-60%. The well-established inverse relationship between plasma HDL-C
levels and the risk of coronary artery disease (CAD) has led to an extensive search for
genetic factors influencing HDL-C concentrations. Over the past 30 years, candidate gene,
genome-wide linkage, and most recently genome-wide association (GWA) studies have
identified several genetic variations for plasma HDL-C levels. However, the functional role of …
