[HTML][HTML] Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C δ mediates the activation
M Tan, X Xu, M Ohba, W Ogawa, MZ Cui - Journal of Biological Chemistry, 2003 - ASBMB
Thrombin plays a critical role in hemostasis, thrombosis, and inflammation. However, the
responsible intracellular signaling pathways triggered by thrombin are still not well defined.
We report here that thrombin rapidly and transiently induces activation of protein kinase D
(PKD) in aortic smooth muscle cells. Our data demonstrate that protein kinase C (PKC)
inhibitors completely block thrombin-induced PKD activation, suggesting that thrombin
induces PKD activation via a PKC-dependent pathway. Furthermore, our results show that …
responsible intracellular signaling pathways triggered by thrombin are still not well defined.
We report here that thrombin rapidly and transiently induces activation of protein kinase D
(PKD) in aortic smooth muscle cells. Our data demonstrate that protein kinase C (PKC)
inhibitors completely block thrombin-induced PKD activation, suggesting that thrombin
induces PKD activation via a PKC-dependent pathway. Furthermore, our results show that …