[HTML][HTML] BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for …
T Kodama, T Takehara, H Hikita, S Shimizu… - Journal of Biological …, 2011 - ASBMB
A pivotal step in the mitochondrial pathway of apoptosis is activation of Bak and Bax,
although the molecular mechanism remains controversial. To examine whether
mitochondrial apoptosis can be induced by just a lack of antiapoptotic Bcl-2-like proteins or
requires direct activators of the BH3-only proteins including Bid and Bim, we studied the
molecular requisites for platelet apoptosis induced by Bcl-xL deficiency. Severe
thrombocytopenia induced by thrombocyte-specific Bcl-xL knock-out was fully rescued in a …
although the molecular mechanism remains controversial. To examine whether
mitochondrial apoptosis can be induced by just a lack of antiapoptotic Bcl-2-like proteins or
requires direct activators of the BH3-only proteins including Bid and Bim, we studied the
molecular requisites for platelet apoptosis induced by Bcl-xL deficiency. Severe
thrombocytopenia induced by thrombocyte-specific Bcl-xL knock-out was fully rescued in a …
