Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo
C Ostrau, J Hülsenbeck, M Herzog, A Schad… - Radiotherapy and …, 2009 - Elsevier
BACKGROUND AND PURPOSE: HMG-CoA-reductase inhibitors (statins) are widely used
lipid-lowering drugs. Moreover, they have pleiotropic effects on cellular stress responses,
proliferation and apoptosis in vitro. Here, we investigated whether lovastatin attenuates
acute and subchronic ionizing radiation-induced normal tissue toxicity in vivo. MATERIALS
AND METHODS: Four hours to 24h after total body irradiation (6Gy) of Balb/c mice, acute
pro-inflammatory and pro-fibrotic responses were analyzed. To comprise subchronic …
lipid-lowering drugs. Moreover, they have pleiotropic effects on cellular stress responses,
proliferation and apoptosis in vitro. Here, we investigated whether lovastatin attenuates
acute and subchronic ionizing radiation-induced normal tissue toxicity in vivo. MATERIALS
AND METHODS: Four hours to 24h after total body irradiation (6Gy) of Balb/c mice, acute
pro-inflammatory and pro-fibrotic responses were analyzed. To comprise subchronic …
