Differential effects of TGF-β on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
OA Gressner, B Lahme, I Demirci, AM Gressner… - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: Connective tissue growth factor (CTGF/CCN2) has been implicated
in the pathogenesis of hepatic fibrosis and suggested as a downstream mediator of the
fibrogenic master cytokine TGF-β. METHODS: We investigated the effect of TGF-β1 on
CTGF/CCN2 expression in cultured rat hepatic stellate cells and hepatocytes by means of
Western and Northern blotting, immunocytochemistry, reporter gene analysis, and metabolic
labelling. RESULTS: We found that the expression of CTGF/CCN2 in hepatic stellate cells is …
in the pathogenesis of hepatic fibrosis and suggested as a downstream mediator of the
fibrogenic master cytokine TGF-β. METHODS: We investigated the effect of TGF-β1 on
CTGF/CCN2 expression in cultured rat hepatic stellate cells and hepatocytes by means of
Western and Northern blotting, immunocytochemistry, reporter gene analysis, and metabolic
labelling. RESULTS: We found that the expression of CTGF/CCN2 in hepatic stellate cells is …
