Molecular evolution of a microRNA cluster
A Tanzer, PF Stadler - Journal of molecular biology, 2004 - Elsevier
Journal of molecular biology, 2004•Elsevier
Many of the known microRNAs are encoded in polycistronic transcripts. Here, we reconstruct
the evolutionary history of the mir17 microRNA clusters which consist of miR-17, miR-18,
miR-19a, miR-19b, miR-20, miR-25, miR-92, miR-93, miR-106a, and miR-106b. The history
of this cluster is governed by an initial phase of local (tandem) duplications, a series of
duplications of entire clusters and subsequent loss of individual microRNAs from the
resulting paralogous clusters. The complex history of the mir17 microRNA family appears to …
the evolutionary history of the mir17 microRNA clusters which consist of miR-17, miR-18,
miR-19a, miR-19b, miR-20, miR-25, miR-92, miR-93, miR-106a, and miR-106b. The history
of this cluster is governed by an initial phase of local (tandem) duplications, a series of
duplications of entire clusters and subsequent loss of individual microRNAs from the
resulting paralogous clusters. The complex history of the mir17 microRNA family appears to …
Many of the known microRNAs are encoded in polycistronic transcripts. Here, we reconstruct the evolutionary history of the mir17 microRNA clusters which consist of miR-17, miR-18, miR-19a, miR-19b, miR-20, miR-25, miR-92, miR-93, miR-106a, and miR-106b. The history of this cluster is governed by an initial phase of local (tandem) duplications, a series of duplications of entire clusters and subsequent loss of individual microRNAs from the resulting paralogous clusters. The complex history of the mir17 microRNA family appears to be closely linked to the early evolution of the vertebrate lineage.
Elsevier
