[HTML][HTML] Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity
UK Hanisch, SA Lyons, M Prinz, C Nolte… - Journal of Biological …, 1997 - ASBMB
The cytokine, interleukin (IL)-15, and the T cell growth factor, IL-2, exhibit a similar spectrum
of immune effects and share the IL-2 receptor (IL-2R) subunits IL-2Rβ and IL-2Rγ for
signaling in hematopoietic cells. Numerous neuroregulatory activities of IL-2 have been
suggested, but its expression in the normal central nervous system (CNS) is apparently very
low and regionally restricted. We show by RNA and protein detection that IL-15, its specific
receptor molecule, IL-15Rα, and the signal-transducing receptor subunits, IL-2Rβ and IL …
of immune effects and share the IL-2 receptor (IL-2R) subunits IL-2Rβ and IL-2Rγ for
signaling in hematopoietic cells. Numerous neuroregulatory activities of IL-2 have been
suggested, but its expression in the normal central nervous system (CNS) is apparently very
low and regionally restricted. We show by RNA and protein detection that IL-15, its specific
receptor molecule, IL-15Rα, and the signal-transducing receptor subunits, IL-2Rβ and IL …
