[HTML][HTML] Soluble interleukin (IL)-15Rα is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15
E Bulanova, V Budagian, E Duitman, Z Orinska… - Journal of biological …, 2007 - ASBMB
Interleukin 15 (IL-15) is a pleiotropic cytokine that is hardly detectable in biological fluids.
Here, we show that IL-15 forms functional heterocomplexes with soluble high affinity IL-15
receptor α (IL-15Rα) chain in mouse serum and cell-conditioned medium, which prevents IL-
15 detection by ELISA. We also demonstrate that two soluble IL-15Rα (sIL-15Rα) sushi
domain isoforms are generated through a novel alternative splicing mechanism within the IL-
15Rα gene. These isoforms potentiate IL-15 action by promoting the IL-15-mediated …
Here, we show that IL-15 forms functional heterocomplexes with soluble high affinity IL-15
receptor α (IL-15Rα) chain in mouse serum and cell-conditioned medium, which prevents IL-
15 detection by ELISA. We also demonstrate that two soluble IL-15Rα (sIL-15Rα) sushi
domain isoforms are generated through a novel alternative splicing mechanism within the IL-
15Rα gene. These isoforms potentiate IL-15 action by promoting the IL-15-mediated …
