[HTML][HTML] Myosin phosphatase-Rho interacting protein: a new member of the myosin phosphatase complex that directly binds RhoA
HK Surks, CT Richards, ME Mendelsohn - Journal of Biological Chemistry, 2003 - ASBMB
Regulation of vascular smooth muscle cell contractile state is critical for the maintenance of
blood vessel tone. Abnormal vascular smooth muscle cell contractility plays an important
role in the pathogenesis of hypertension, blood vessel spasm, and atherosclerosis. Myosin
phosphatase, the key enzyme controlling myosin light chain dephosphorylation, regulates
smooth muscle cell contraction. Vasoconstrictor and vasodilator pathways inhibit and
activate myosin phosphatase, respectively. G-protein-coupled receptor agonists can inhibit …
blood vessel tone. Abnormal vascular smooth muscle cell contractility plays an important
role in the pathogenesis of hypertension, blood vessel spasm, and atherosclerosis. Myosin
phosphatase, the key enzyme controlling myosin light chain dephosphorylation, regulates
smooth muscle cell contraction. Vasoconstrictor and vasodilator pathways inhibit and
activate myosin phosphatase, respectively. G-protein-coupled receptor agonists can inhibit …
