[PDF][PDF] Cell immortality and hallmarks of cancer
MV Blagosklonny - Cell Cycle, 2003 - Taylor & Francis
Cell Cycle, 2003•Taylor & Francis
CC 2/4 inside pages Page 1 ©2003 Landes Bioscience. Not for distribution. ABSTRACT In
growth-limiting conditions, cells that express telomerase and inactivate tumor suppressors
have a selective advantage due to resistance to growth arrest. Accidentally such cells become
immortal. PARADOX OF IMMORTALITY Cell immortality is a mysterious hallmark of cancer,
because it is difficult to explain how selection for immortality occurs. Limitless life span cannot
provide any immediate advantage. Unless a cell can tell the future. In other words, a cell must …
growth-limiting conditions, cells that express telomerase and inactivate tumor suppressors
have a selective advantage due to resistance to growth arrest. Accidentally such cells become
immortal. PARADOX OF IMMORTALITY Cell immortality is a mysterious hallmark of cancer,
because it is difficult to explain how selection for immortality occurs. Limitless life span cannot
provide any immediate advantage. Unless a cell can tell the future. In other words, a cell must …
In growth-limiting conditions, cells that express telomerase and inactivate tumor suppressors have a selective advantage due to resistance to growth arrest. Accidentally such cells become immortal.
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