[HTML][HTML] Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
A Geick, M Eichelbaum, O Burk - Journal of Biological Chemistry, 2001 - ASBMB
Intestinal P-glycoprotein, which is encoded by the MDR1 gene, plays an important role in the
absorption and presystemic elimination of many xenobiotics. Hence, an understanding of
the factors regulating its expression and function is of substantial interest. In addition to
genetic factors, exposure to drugs such as rifampin can profoundly affect its expression. So
far, the mechanisms by which rifampin induces MDR1 expression are poorly understood.
Recent studies demonstrate that the nuclear receptor PXR (pregnane X receptor) is involved …
absorption and presystemic elimination of many xenobiotics. Hence, an understanding of
the factors regulating its expression and function is of substantial interest. In addition to
genetic factors, exposure to drugs such as rifampin can profoundly affect its expression. So
far, the mechanisms by which rifampin induces MDR1 expression are poorly understood.
Recent studies demonstrate that the nuclear receptor PXR (pregnane X receptor) is involved …
