[HTML][HTML] Src Phosphorylation of the Epidermal Growth Factor Receptor at Novel Sites Mediates Receptor Interaction with Src and P85α (∗)
DR Stover, M Becker, J Liebetanz, NB Lydon - Journal of Biological …, 1995 - ASBMB
Following ligand binding, the epidermal growth factor receptor (EGF-R) autophosphorylates
itself on tyrosine residues located in its carboxyl terminus; in vitro, three sites are highly
phosphorylated, while two other sites are phosphorylated to lesser extents. In the presence
of the Src protein-tyrosine kinase, in vitro phosphorylation of the minor autophosphorylation
sites was increased, and four additional residues were phosphorylated. Following EGF
stimulation, two (Tyr-891 and Tyr-920) were found to be phosphorylated in a colorectal cell …
itself on tyrosine residues located in its carboxyl terminus; in vitro, three sites are highly
phosphorylated, while two other sites are phosphorylated to lesser extents. In the presence
of the Src protein-tyrosine kinase, in vitro phosphorylation of the minor autophosphorylation
sites was increased, and four additional residues were phosphorylated. Following EGF
stimulation, two (Tyr-891 and Tyr-920) were found to be phosphorylated in a colorectal cell …
