[HTML][HTML] Regulation of NAD (P) H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells
M Janiszewski, LR Lopes, AO Carmo, MA Pedro… - Journal of Biological …, 2005 - ASBMB
NAD (P) H oxidase, the main source of reactive oxygen species in vascular cells, is known to
be regulated by redox processes and thiols. However, the nature of thiol-dependent
regulation has not been established. Protein disulfide isomerase (PDI) is a dithiol/disulfide
oxidoreductase chaperone of the thioredoxin superfamily involved in protein processing and
translocation. We postulated that PDI regulates NAD (P) H oxidase activity of rabbit aortic
smooth muscle cells (VSMCs). Western blotting confirmed robust PDI expression and shift to …
be regulated by redox processes and thiols. However, the nature of thiol-dependent
regulation has not been established. Protein disulfide isomerase (PDI) is a dithiol/disulfide
oxidoreductase chaperone of the thioredoxin superfamily involved in protein processing and
translocation. We postulated that PDI regulates NAD (P) H oxidase activity of rabbit aortic
smooth muscle cells (VSMCs). Western blotting confirmed robust PDI expression and shift to …