[HTML][HTML] Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages
MW Feinberg, Z Cao, AK Wara, MA Lebedeva… - Journal of Biological …, 2005 - ASBMB
Activation of macrophages is important in chronic inflammatory disease states such as
atherosclerosis. Proinflammatory cytokines such as interferon-γ (IFN-γ), lipopolysaccharide
(LPS), or tumor necrosis factor-α can promote macrophage activation. Conversely, anti-
inflammatory factors such as transforming growth factor-β1 (TGF-β1) can decrease
proinflammatory activation. The molecular mediators regulating the balance of these
opposing effectors remain incompletely understood. Herein, we identify Kruppel-like factor 4 …
atherosclerosis. Proinflammatory cytokines such as interferon-γ (IFN-γ), lipopolysaccharide
(LPS), or tumor necrosis factor-α can promote macrophage activation. Conversely, anti-
inflammatory factors such as transforming growth factor-β1 (TGF-β1) can decrease
proinflammatory activation. The molecular mediators regulating the balance of these
opposing effectors remain incompletely understood. Herein, we identify Kruppel-like factor 4 …