[HTML][HTML] Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation
S Cathelin, C Rebe, L Haddaoui, N Simioni… - Journal of Biological …, 2006 - ASBMB
We have shown previously that caspases were specifically involved in the differentiation of
peripheral blood monocytes into macrophages while not required for monocyte
differentiation into dendritic cells. To identify caspase targets in monocytes undergoing
macrophagic differentiation, we used the human monocytic leukemic cell line U937, whose
macrophagic differentiation induced by exposure to 12-O-tetradecanoylphorbol 13-acetate
(TPA) can be prevented by expression of the baculovirus caspase-inhibitory protein p35. A …
peripheral blood monocytes into macrophages while not required for monocyte
differentiation into dendritic cells. To identify caspase targets in monocytes undergoing
macrophagic differentiation, we used the human monocytic leukemic cell line U937, whose
macrophagic differentiation induced by exposure to 12-O-tetradecanoylphorbol 13-acetate
(TPA) can be prevented by expression of the baculovirus caspase-inhibitory protein p35. A …