[HTML][HTML] Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs)
W Richter, M Conti - Journal of Biological Chemistry, 2002 - ASBMB
The cAMP-specific PDE4 family consists of four genes, each expressed as several splice
variants. These variants are termed long and short forms depending on the presence or
absence of two unique N-terminal domains called upstream conserved regions 1 and 2
(UCR1 and 2). UCR1 and UCR2 have been shown to form a module necessary for the
activation of PDE4 upon phosphorylation by the cAMP-dependent kinase (PKA). Here we
have uncovered PDE4 oligomerization as a novel function for the UCR1/UCR2 module …
variants. These variants are termed long and short forms depending on the presence or
absence of two unique N-terminal domains called upstream conserved regions 1 and 2
(UCR1 and 2). UCR1 and UCR2 have been shown to form a module necessary for the
activation of PDE4 upon phosphorylation by the cAMP-dependent kinase (PKA). Here we
have uncovered PDE4 oligomerization as a novel function for the UCR1/UCR2 module …
