[HTML][HTML] The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis
JR Goudriaan, SMSE Santo, PJ Voshol, B Teusink… - Journal of lipid …, 2004 - ASBMB
The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived
FFA by facilitating the expression of lipoprotein lipase (LPL). However, vldlr−/− mice do not
show altered plasma lipoprotein levels, despite reduced LPL expression. Because LPL
activity is crucial in postprandial lipid metabolism, we investigated whether the VLDLr plays
a role in chylomicron clearance. Fed plasma TG levels of vldlr−/− mice were 2.5-fold
increased compared with those of vldlr+/+ littermates (1.20±0.37 mM vs. 0.47±0.18 mM; P< …
FFA by facilitating the expression of lipoprotein lipase (LPL). However, vldlr−/− mice do not
show altered plasma lipoprotein levels, despite reduced LPL expression. Because LPL
activity is crucial in postprandial lipid metabolism, we investigated whether the VLDLr plays
a role in chylomicron clearance. Fed plasma TG levels of vldlr−/− mice were 2.5-fold
increased compared with those of vldlr+/+ littermates (1.20±0.37 mM vs. 0.47±0.18 mM; P< …