Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a …
M Rosenblat, J Vaya, D Shih, M Aviram - Atherosclerosis, 2005 - Elsevier
We investigated the role of HDL-associated paraoxonase 1 (PON1) in HDL-mediated
macrophage cholesterol efflux by using HDL derived from wild type mice (Control-HDL),
from human PON1-transgenic mice (HDL-PON1Tg) or from PON1-knockout mice (HDL-
PON10). Cholesterol efflux from mouse peritoneal macrophages (MPM) or from J774 A. 1
macrophage cell line by HDL-PON1Tg, was significantly increased (by 60%) compared to
HDL-PON10. We demonstrated that this PON1 effect was associated with an increased HDL …
macrophage cholesterol efflux by using HDL derived from wild type mice (Control-HDL),
from human PON1-transgenic mice (HDL-PON1Tg) or from PON1-knockout mice (HDL-
PON10). Cholesterol efflux from mouse peritoneal macrophages (MPM) or from J774 A. 1
macrophage cell line by HDL-PON1Tg, was significantly increased (by 60%) compared to
HDL-PON10. We demonstrated that this PON1 effect was associated with an increased HDL …
