Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice
SH Sung, FN Ziyadeh, A Wang… - Journal of the …, 2006 - journals.lww.com
For investigation of how the vascular endothelial growth factor (VEGF) system participates in
the pathogenesis of diabetic kidney disease, type 2 diabetic db/db and control db/m mice
were treated intraperitoneally with vehicle or 2 mg/kg of a pan-VEGF receptor tyrosine
kinase inhibitor, SU5416, twice a week for 8 wk. Efficacy of SU5416 treatment in the kidney
was verified by the inhibition of VEGF receptor-1 phosphorylation. Glomerular VEGF
immunostaining, normally increased in diabetes, was unaffected by SU5416. Plasma …
the pathogenesis of diabetic kidney disease, type 2 diabetic db/db and control db/m mice
were treated intraperitoneally with vehicle or 2 mg/kg of a pan-VEGF receptor tyrosine
kinase inhibitor, SU5416, twice a week for 8 wk. Efficacy of SU5416 treatment in the kidney
was verified by the inhibition of VEGF receptor-1 phosphorylation. Glomerular VEGF
immunostaining, normally increased in diabetes, was unaffected by SU5416. Plasma …