[HTML][HTML] Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes
V Subramanian, A Rothenberg, C Gomez… - Journal of Biological …, 2004 - ASBMB
Perilipins, the major structural proteins coating the surfaces of mature lipid droplets of
adipocytes, play an important role in the regulation of triacylglycerol storage and hydrolysis.
We have used proteomic analysis to identify CGI-58, a member of the α/β-hydrolase fold
family of enzymes, as a component of lipid droplets of 3T3-L1 adipocytes. CGI-58 mRNA is
highly expressed in adipose tissue and testes, tissues that also express perilipins, and at
lower levels in liver, skin, kidney, and heart. Both endogenous CGI-58 and an ectopic CGI …
adipocytes, play an important role in the regulation of triacylglycerol storage and hydrolysis.
We have used proteomic analysis to identify CGI-58, a member of the α/β-hydrolase fold
family of enzymes, as a component of lipid droplets of 3T3-L1 adipocytes. CGI-58 mRNA is
highly expressed in adipose tissue and testes, tissues that also express perilipins, and at
lower levels in liver, skin, kidney, and heart. Both endogenous CGI-58 and an ectopic CGI …