Human genetics illuminates the paths to metabolic disease
S O'Rahilly - Nature, 2009 - nature.com
Nature, 2009•nature.com
Metabolic diseases represent a growing threat to world-wide public health. In general, these
disorders result from the interaction of heritable factors with environmental influences. Here,
I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and
explore the extent to which human molecular genetic research has illuminated our
understanding of their underlying pathophysiological mechanisms.
disorders result from the interaction of heritable factors with environmental influences. Here,
I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and
explore the extent to which human molecular genetic research has illuminated our
understanding of their underlying pathophysiological mechanisms.
Abstract
Metabolic diseases represent a growing threat to world-wide public health. In general, these disorders result from the interaction of heritable factors with environmental influences. Here, I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and explore the extent to which human molecular genetic research has illuminated our understanding of their underlying pathophysiological mechanisms.
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