The persistence of T cell memory
MA Daniels, E Teixeiro - Cellular and molecular life sciences, 2010 - Springer
Cellular and molecular life sciences, 2010•Springer
T cell memory is a crucial feature of the adaptive immune system in the defense against
pathogens. During the last years, numerous studies have focused their efforts on uncovering
the signals, inflammatory cues, and extracellular factors that support memory differentiation.
This research is beginning to decipher the complex gene network that controls memory
programming. However, how the different signals, that a T cell receives during the process of
differentiation, interplay to trigger memory programming is still poorly defined. In this review …
pathogens. During the last years, numerous studies have focused their efforts on uncovering
the signals, inflammatory cues, and extracellular factors that support memory differentiation.
This research is beginning to decipher the complex gene network that controls memory
programming. However, how the different signals, that a T cell receives during the process of
differentiation, interplay to trigger memory programming is still poorly defined. In this review …
Abstract
T cell memory is a crucial feature of the adaptive immune system in the defense against pathogens. During the last years, numerous studies have focused their efforts on uncovering the signals, inflammatory cues, and extracellular factors that support memory differentiation. This research is beginning to decipher the complex gene network that controls memory programming. However, how the different signals, that a T cell receives during the process of differentiation, interplay to trigger memory programming is still poorly defined. In this review, we focus on the most recent advances in the field and discuss how T cell receptor signaling and inflammation control CD8 memory differentiation.
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