Secretory IgA (SIgA), the predominant class of antibody in intestinal secretions, serves as
the first line of defense against enteric infections. SIgA has also been proposed to function in
immune surveillance, given that both SIgA and SIgA-antigen complexes are actively
transported by Peyer's patch M cells from the intestinal lumen to sub-epithelial dendritic cells
(DCs). The goal of the present study was to identify the receptor (s) potentially utilized by
mucosal DCs to recognize and internalize SIgA. We demonstrate that human colostral SIgA …