Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival
X Wang, X Tang, M Li, J Marshall, Z Mao - Journal of Biological Chemistry, 2005 - ASBMB
The transcription factor myocyte-enhancer factor 2 (MEF2) has been shown to be required
for the survival of different types of neurons. However, the death-or survival-inducing second
messenger pathways that regulate MEF2 activity remain to be fully elucidated. Membrane
depolarization by KCl induces neuronal survival that is dependent upon MEF2-mediated
gene transactivation. Here we report that membrane depolarizationinduced activation of
MEF2 requires the cAMP-protein kinase A (PKA) pathway. Inhibition of the activity of cAMP …
for the survival of different types of neurons. However, the death-or survival-inducing second
messenger pathways that regulate MEF2 activity remain to be fully elucidated. Membrane
depolarization by KCl induces neuronal survival that is dependent upon MEF2-mediated
gene transactivation. Here we report that membrane depolarizationinduced activation of
MEF2 requires the cAMP-protein kinase A (PKA) pathway. Inhibition of the activity of cAMP …
