Cyclins and Cyclin–Dependent Kinases: Comparative Study of Hepatocellular Carcinoma Versus Cirrhosis
T Masaki, Y Shiratori, W Rengifo, K Igarashi… - Hepatology, 2003 - journals.lww.com
Increasing evidence has indicated that perturbation of cyclins is one of the major factors
leading to cancer. The aim of this study was not only to investigate various cell cycle–related
kinase activities in hepatocellular carcinoma (HCC), but also to analyze the difference of cell
cycle–related kinase activity levels between hepatitis C virus (HCV)–induced HCC and HCV–
induced cirrhosis. The protein levels of cyclins D1, E, A, and H, and of cyclin dependent
kinase 1 (Cdk1), Cdk2, Cdk4, Cdk6, and Cdk7 in HCC and in surrounding nontumorous …
leading to cancer. The aim of this study was not only to investigate various cell cycle–related
kinase activities in hepatocellular carcinoma (HCC), but also to analyze the difference of cell
cycle–related kinase activity levels between hepatitis C virus (HCV)–induced HCC and HCV–
induced cirrhosis. The protein levels of cyclins D1, E, A, and H, and of cyclin dependent
kinase 1 (Cdk1), Cdk2, Cdk4, Cdk6, and Cdk7 in HCC and in surrounding nontumorous …
