Amblyomma americanum: requirement for host Fc receptors in antibody-mediated acquired immune resistance to ticks

SJ Brown, PW Askenase - Experimental parasitology, 1985 - Elsevier
Guinea pig recipients of anti-tick immune serum or immune peritoneal exudate cells
expressed 25 and 30% tick rejection, respectively, when challenged with Amblyomma
americanum larval ticks. Previous studies have shown that IgG 1 antibodies are responsible
for the ability of immune serum to transfer resistance to ticks and to mediate the
accompanying, and required, cutaneous basophil response. Since IgG 1 antibodies induce
mast cell-mediated passive cutaneous anaphylaxis and cutaneous basophil responses by …